2017 Fiscal Year Final Research Report
Reciprocity between robustness and plasticity in the circadian clock
| Project/Area Number |
15K18512
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 理論生物物理学 / 頑健性 / 可塑性 / 力学系 / 非線形 |
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| Outline of Final Research Achievements |
Circadian clocks exhibit the robustness of period and plasticity of phase against environmental changes such as temperature and nutrient conditions. Thus far, however, it is unclear how both are simultaneously achieved. By investigating distinct models of circadian clocks, we demonstrate reciprocity between robustness and plasticity: higher robustness in the period implies higher plasticity in the phase. I demonstrated that the robustness of period is achieved by the adaptation on the limit cycle, which causes reciprocity.
I also found that reciprocity between robustness and plasticity is achieved in a variety of biological phenomena, i.e., spatial pattern formation and gene regulatory dynamics. It suggests that such reciprocity is universal in many biological activities.
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| Free Research Field |
理論生物物理学
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