Analysis for transcriptional regulation mechanism of retrotransposon

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18578
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Genetics/Chromosome dynamics
• Research Institution: Okayama University
• Principal Investigator: Ikeda Yoko 岡山大学, 資源植物科学研究所, 特任助教 (80467688)
• Research Collaborator: MATHIEU Olivier クレルモンフェラン大学, Principal investigator
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: トランスポゾン / エピジェネティクス / サイレンシング

Outline of Final Research Achievements

To reveal the transcriptional regulation mechanism of retrotransposons, we carried out a screen of the mutants affected in the silencing at a transgene. We identified Arabidopsis gene affecting heterochromatin-associated silencing, KUMONOSU (KUN). KUN encodes a plant-specific retrotransposon related plant mobile domain (PMD), and affects silencing pathway by impaired condensation of pericentromeric heterochromatin. KUN acts for silencing independent of DNA methylation and known chromatin modifications.

Free Research Field

植物分子遺伝学