2017 Fiscal Year Final Research Report
Understanding the relationship between aerobic energy metabolisms and cell cycle progression in eukaryotes.
| Project/Area Number |
15K18588
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Evolutionary biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 真核藻類 / 概日リズム / 細胞周期 / 遺伝子改変 / 植物 |
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| Outline of Final Research Achievements |
Mitochondria and chloroplasts perform highly efficient energy metabolisms, respiration and photosynthesis, respectively, in eukaryotes. The aerobic energy metabolisms, however, are also main generators of reactive oxygen species and can damage cells. It has been poorly known how eukaryotic cells coordinate the aerobic energy metabolisms for safe cell proliferation during a daily cycle. Eukaryotic algae grow during the daytime. In contrast, the cell cycle progression is restricted to the night when photosynthesis does not operate. This temporal separation protects S- and M-phase cells from photosynthetic oxidative stress. Circadian rhythms are believed to control this temporal separation. We demonstrated that change in photosynthetic activity resets the circadian rhythms, which suggests that the timing of cell cycle progression, which is regulated by circadian rhythms, are probably determined by interaction between the molecular clock in a host and retrograde signals from endosymbionts.
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| Free Research Field |
細胞生物学
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