2017 Fiscal Year Annual Research Report
Identifying genetic loci related to the unique phenotypes and immune system of the Negrito populations in Southeast Asia
| Project/Area Number |
15K18622
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
Jinam TimothyA 国立遺伝学研究所, 集団遺伝研究系, 助教 (20648258)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Negrito / Southeast Asia / HLA / genome-wide SNP |
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| Outline of Annual Research Achievements |
Genome-wide SNP analysis of Negrito populations from Southeast Asia was completed. Comparing this data with other human populations, the Negritos were phylogenetically basal to other Southeast and East Asians, with divergence times estimated to be at least 30 thousand years ago. The Philippine Negritos showed relatively high traces of Denisovan ancestry, but not in Malaysian or Andamanese Negritos. Some of the SNP that were shared between all Negrito groups were associated with height, facial morphology and malarial resistance. There results were published in Genome Biology and Evolution in 2017. Sequencing of HLA genes in seven populations from Malaysia using HiSeq sequencer was completed. Data analysis of these data has been completed and manuscript preparation of these data is ongoing.
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Research Products
(2 results)
