Interspecific analysis of stabilization mechanism of a transcription factor in response to drought and heat stresses

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18652
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plant protection science
• Research Institution: The University of Tokyo
• Principal Investigator: Mizoi Junya 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (20469753)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 植物 / 非生物ストレス応答 / 高温ストレス / 転写因子 / 翻訳後制御 / リン酸化 / プロテインキナーゼ / 安定性制御

Outline of Final Research Achievements

DREB2A is a transcription factor that plays important roles in response to drought and heat stresses in Arabidopsis. While DREB2A is rapidly degraded under normal conditions, it is stabilized in response to these stresses to activate expression of downstream stress-responsive genes. However, the mechanism underlying the conditional changes of DREB2A stability in response to stresses remains to be elucidated.
In this study, we found that stress-dependent change of DREB2A phosphorylation enables stability regulation according to environmental changes. As an important sequence motif for phosphorylation is functionally conserved among angiosperms, similar regulatory mechanisms is expected to function in other angiosperms.

Free Research Field

植物科学