2017 Fiscal Year Final Research Report
The epigenetics-driven adaptive evolution concept and its application to microbe engineering
| Project/Area Number |
15K18665
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | University of Tsukuba (2016-2017)
The University of Tokyo (2015) |
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Principal Investigator |
Yano Hirokazu 筑波大学, 生命環境系, 研究員 (20646773)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ゲノム / ピロリ菌 / メチローム |
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| Outline of Final Research Achievements |
We revealed the functionality of diverse methyltransferase genes in the pathogen (H. pylori) genome. We established experimental and analytical protocols for bacterial methylome and transcriptome studies. We discovered an epigenetic network consisting of multiple regulatory networks governed by site-specific DNA methyltransferases. We discovered a novel restriction-modification system potentially useful for epigenome engineering.
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| Free Research Field |
ゲノム微生物学
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