2016 Fiscal Year Final Research Report
Development of selective antagonist of COI1-JAZ receptor
| Project/Area Number |
15K18687
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | アゴニスト / 植物ホルモン / コロナチン |
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| Outline of Final Research Achievements |
In this study, JAZ subtype-selective agonists, which selectively activate useful functions among diverse physiological roles by jasmonic acids signaling, are developed based on coronatine which is a mimic of jasmonoyl-L-isoleucine with potent activities. A lead compound used for JAZ selective agonist development was found using an evaluation system of pull-down assay system COI1-JAZ interaction using JAZ fragment peptide which is a binding domain with COI1 of JAZ. Based on the knowledge, we designed several compounds that are thought to be more selective improvement by in silico docking study. By a similar pull-down assay, two subtype-selective agonists that bind to some of JAZ were found among them.
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| Free Research Field |
ケミカルバイオロジー
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