Effect of dietary sphingolipids on the absorption of nutrients

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18693
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Hokkaido University
• Principal Investigator: SAKAI Shota 北海道大学, 先端生命科学研究院, 特任助教 (60611720)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: スフィンゴ脂質 / 栄養素 / トランスポーター

Outline of Final Research Achievements

Glucosylceramides and their sphingoid bases were purified from various food materials and the effect of these sphingolipids on the mRNA expression of the transporter of various nutrients was investigated. The levels of mRNA of transporters related to minerals, such as calcium and magnesium, were significantly increased by the treatment of glucosylceramide and sphingoid base from plants and fungi. Futhermore, These sphingolipids facilitated the dimerization of CTR1 protein, which is involved in the incorporation of copper, and increased the contents of glycosylated iron transporter DMT-1 protein.

Free Research Field

脂質生化学