The effect of mitochondrial oxidative stress on the hypertension induced by dietary sodium intake.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18694
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Tohoku University
• Principal Investigator: OHSAKI YUSUKE 東北大学, 医学系研究科, 助教 (40509212)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 食塩 / 高血圧 / 酸化ストレス / 腎障害 / ミトコンドリア / ナトリウム貯留 / 腎臓髄質血流 / 体液貯留

Outline of Final Research Achievements

Oxidative stress production in the renal medullary region contributes to increase blood pressure. The contribution of NAD(P)H oxidase derived oxidative stress in the renal medullary region has been well investigated, while the contribution of mitochondrial oxidative stress production is still unclear. We fed high salt diet to salt sensitive hypertension model animals, and infused TEMPOL or MitoTEMPO simultaneously. High salt diet treatment significantly increased systolic blood pressure and urinary albumin excretion. Treatment with TEMPO and MitoTEMPO tended to attenuate the increase of blood pressure and urinary albumin excretion, however did not reached to significant level.

Free Research Field

腎臓生理学