2016 Fiscal Year Final Research Report
Study for novel function of branched-chain amino acids
| Project/Area Number |
15K18696
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 分岐鎖アミノ酸 / 分岐鎖アミノ酸分解系 / 脂肪組織 / コンディショナルノックアウトマウス |
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| Outline of Final Research Achievements |
The catabolism of branched-chain amino acids (BCAA) is regulated by the mitochondrial branched-chain α-keto acid dehydrogenase kinase (BDK). In this study, we generated adipose tissue-specific BDK deficient mice (BDK-aKO mice) and investigated its characteristics. BCAAs were lower in white adipose tissues and brown adipose tissue as well as in plasma of BDK-aKO mice compared to control mice. Moreover we revealed that cold exposure-induced mRNA expression of PGC-1α in brown adipose tissue was increased in BDK-aKO mice.
These results suggested that BCAA catabolism in adipose tissues affected BCAA levels in whole body and energy consumption in brown adipose tissue.
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| Free Research Field |
栄養生化学
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