Maternal immune strategy to recognize conceptus in mammals

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18767
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Animal production science
• Research Institution: The University of Tokyo
• Principal Investigator: Kusama Kazuya 東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (30579149)
• Research Collaborator: IMAKAWA Kazuhiko 東京大学, 大学院農学生命科学研究科, 教授 (00291956)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 着床 / IFNT / ウシ / エクソソーム / 免疫寛容

Outline of Final Research Achievements

We demonstrated novel regulatory mechanisms by which bovine IFNTs were regulated by transcriptional factors TEAD2, TEAD4 and YAP1. In addition, two IFNTs, IFNT2 and IFN-tau-c1, were regulated by different transcription factors. In this study, IFNT up-regulated immune- and antigen presentation-related genes in bovine endometrium, indicating that IFNT regulated immune system against conceptus in pre-implantation endometrium.
We identified that conceptus-derived exosome exists in bovine and ovine endometrial lumen, and its components differed during peri-implatantion periods. We further indicated that conceptus-derived exosome regulated endometrial condition essential for the conceptus implantation in pre-implantation periods.

Free Research Field

繁殖分子生物科学