2017 Fiscal Year Final Research Report
Pathological study on the formation of ectopic granule cells in the hippocampus of rat model of epilepsy
| Project/Area Number |
15K18781
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 神経病理 / 脳 / てんかん / 海馬 |
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| Outline of Final Research Achievements |
Ectopic granule cells, which is observed in the hilus of the hippocampus, is considered to relate the epileptogenesis or progression of epileptic signs due to the formation of aberrant neural network. However, the mechanisms of ectopic granule cell formation are not well known. In this study, we immunohistochemically examined the brain of pilocarpine-treated rat of epilepsy model. From our results, it is suggested that microglial activation and survivin expression in the immature neurons are involved in the mechanisms of ectopic granule cell formation.
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| Free Research Field |
獣医病理
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