2016 Fiscal Year Final Research Report
Development of novel therapeutic strategies for canine fibrosarcoma by RNA interference
| Project/Area Number |
15K18792
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Veterinary medical science
|
|---|
| Research Institution | Gifu University |
|---|
Principal Investigator |
Murakami Mami 岐阜大学, 応用生物科学部, 助教 (30597125)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | イヌ線維肉腫 |
|---|
| Outline of Final Research Achievements |
Fascin-1 is a 54 kDa actin-binding protein and plays an important role in regulating cell adhesion as well as coordinating cell motility and invasion in physiological and pathogenic condition. Canine Fibrosarcoma is a malignant mesenchymal tumor and very locally invasive which often recurs following surgery. It is assumed that recurrence has relation with Fascin-1. Strong Fascin-1 protein expression has revealed in canine fibrosarcoma by immunohistochemistly. Furthermore, a suppressive tendency on cell migration in canine fibrosarcoma cell line by suppressing Fascin-1 was detected.
Fascin-1 targeted therapy may represent a new strategy for the canine fibrosarcoma treatment.
|
| Free Research Field |
獣医学
|
