2016 Fiscal Year Final Research Report
Site-Selevctive Molecular Transformation based on Activation of Catalytic Intermediate via Counterion Exchange
| Project/Area Number |
15K18827
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Kyoto University |
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Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 求核触媒 / カウンターアニオン / 位置選択性 |
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| Outline of Final Research Achievements |
We have proposed a new catalytic cycle for catalytic site-selective acylation of a carbohydrate based on quantitative analysis of reactivity of the catalytic intermediate. Catalyst loading was successfully decreased from 10 mol% to less than 0.1 mol%. Introduction of various substituted benzoyl groups were achieved site-selectively, which indicate that the reaction is applicable for efficient total synthesis of natural glycosides.
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| Free Research Field |
医歯薬学
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