2016 Fiscal Year Final Research Report
Development of novel asymmetric catalyst based on piperazinone derivatives
| Project/Area Number |
15K18829
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NAKAO Michiyasu 徳島大学, 大学院医歯薬学研究部(薬学系), 助教 (60550001)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | ピペラジノン / 不斉触媒 / 不斉アルドール反応 / 環状炭酸エステル / 非対称化反応 |
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| Outline of Final Research Achievements |
We investigated that development of novel asymmetric catalyst based on piperazinone derivatives. As a result, we demonstrated that novel piperazinone bearing a primary amino group could catalyze asymmetric aldol reaction between hydroxyacetone and p-nitrobenzaldehyde. In addition, novel piperazinone bearing a tertiary amino group was found to catalyze asymmetric desymmetrization of σ-symmetric cyclic carbonates.
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| Free Research Field |
有機化学
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