2016 Fiscal Year Final Research Report
Efficient synthesis of compounds having various substitution patterns using ligand-controlled site-selective reactions
| Project/Area Number |
15K18833
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 触媒 / 位置選択性 / 配位子 |
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| Outline of Final Research Achievements |
In this study, ligand-controlled site-selective reactions, which are powerful tools for effective synthesis of multisubstituted compounds, were developed. Dihydroxyterphenylphosphine (DHTP), which was previously developed by our group, was employed as a ligand, and various reactions were screened using a catalyst derived palladium and DHTP. As a result, arylation of nonsubstituted indole with chloroarenes proceeded C3-selectively using Pd-DHTP catalyst. On the other hand, other commercially available ligands used in cross coupling of chloroarenes afforded N-arylated product selectively. In addition, several DHTP analogs were designed as a new ligands and synthesized. These ligand showed different reactivity and site-selectivity from those of DHTP.
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| Free Research Field |
有機化学
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