2017 Fiscal Year Final Research Report
Development of practicality-oriented synthetic organic reactions using toxic gas surrogates
| Project/Area Number |
15K18834
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MANABE Kei 静岡県立大学, 薬学部, 教授 (00251439)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 毒性ガス / 等価体 / 一酸化炭素 / 二酸化硫黄 / パラジウム / 触媒 / 安全 / 実用的 |
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| Outline of Final Research Achievements |
We have developed safe and practical synthetic organic reactions using "toxic gas surrogates" already developed by our laboratory that could generate toxic gases such as carbon monoxide by chemical reactions. In this study, various catalytic carbonylative reactions by using carbon monoxide surrogates could be realized. In addition, we showed that sulfonamides and sulfinamides could be synthesized with complete selectivity using a known sulfur dioxide surrogate for the first time. These results are highly innovative in terms of converting gas-phase reactions using dangerous toxic gases into safe and efficient liquid-phase reactions using their surrogates, and are expected to be used extensively in the future.
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| Free Research Field |
有機合成化学
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