2017 Fiscal Year Final Research Report
Development of Catalytic Aerobic Oxidation Using Photoswitchable Porphyrin Dimers
| Project/Area Number |
15K18839
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 光スイッチ / アゾ構造 / 光異性化 / ポルフィリン二量体 / 酸化触媒 / 酸素 / アミノ化 / 絶対配置 |
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| Outline of Final Research Achievements |
Synthesis, characterization, and photo- and electrochemical properties of photoswitchable azo-linked porphyrin dimers that can catalyze aerobic oxidations of organic molecules were explored, and following results were obtained. 1) Primary amino-substituted free-base porphyrins, the key synthon for the preparation of the desired azo-linked porphyrin dimer, can be synthesized via palladium-catalyzed coupling of bromoporphyrins with ammonium sulfate as a nitrogen source. In addition to these studies, 2) we have developed a direct protocol for the determination of the absolute configurations of chiral mono-alcohols and epoxides using a CD-sensitive porphyrin dimer as a host molecule, which can effectively capture both oxygen atom lone pairs through simultaneous coordination with the two central metals of the porphyrin subunits.
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| Free Research Field |
化学系薬学（物理有機化学）
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