2016 Fiscal Year Final Research Report
Functional analysis of novel phosphoinositide metabolites
| Project/Area Number |
15K18857
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 質量分析 / リピドミクス / ホスホイノシタイド / 生理活性 |
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| Outline of Final Research Achievements |
Phosphoinositide (PIP) is a membrane phospholipid composed of diacylglycerol and a D-myo-inositol head group. In mammals, the hydroxyl groups at the D3, D4 and D5 positions of the inositol ring can be phosphorylated to yield seven phosphoinositide derivatives. Recently, we developed high sensitivity PIPs detection method using LC-MS/MS system. Additionally, in the process of detecting PIPs in various biological samples, we found lysoPIPs which is detected at high levels in mouse cancer tissue. The aim of this study is to elucidate the physiological functions of PIPs and novel lysoPIPs and the pathological mechanism caused by PIPs metabolic abnormality. Future work, we aim to establish non-invasive biomarkers using blood sample. The development of novel biomarkers using phosphoinositide profiling is a world's first and an epoch-making attempt.
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| Free Research Field |
脂質生物学
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