Identification and analysis of genes regulatiing Atg5-independent autophagy

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18860
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Yamaguchi Hirofumi 東京医科歯科大学, 難治疾患研究所, プロジェクト助教 (50644241)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: オートファジー / 遺伝学

Outline of Final Research Achievements

Autophagy is a process that degrades subcellular constituents. We previously discovered Atg5/Atg7-independent alternative autophagy, and this pathway is phylogenetically conserved from yeast to mammals. Here, we identified genes regulating alternative autophagy in yeast by using yeast genetic screen, and analyzed the role in the autophagy. Moreover, we identified mammalian homologue of these genes, and we found that these genes are required for alternative autophagy in mammals. However, these genes are not involved in starvation-induced conventional autophagy, suggesting that these genes are specific to alternative autophagy.

Free Research Field

細胞生物学