2016 Fiscal Year Final Research Report
Role of Rab family proteins in regulation of antigen presentation in dendritic cells
| Project/Area Number |
15K18864
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
Furuta Kazuyuki 岡山大学, 医歯薬学総合研究科, 准教授 (50644936)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 抗原提示 / 樹状細胞 / MHC-II / Rab |
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| Outline of Final Research Achievements |
MHC-II expressed on antigen presenting cells such as dendritic cells presents antigenic peptides to CD4 T cells and initiates acquired immunity. The cell-surface expression of MHC-II is tightly regulated, however, the regulation mechanism remains to be clarified. In this study we obtained the following results: 1. MHC-II closslinking induced intracellular Ca2+ influx was required for MHC-II endocytosis. 2. LPS induced Rab11 expression in dendritic cells.
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| Free Research Field |
生物系薬学
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