2016 Fiscal Year Final Research Report
Physiological and pathophysiological roles of an orphan G protein-coupled receptor
Project/Area Number |
15K18867
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
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Research Institution | Teikyo University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 脂質生化学 / リゾリン脂質 / Gタンパク質共役型受容体 |
Outline of Final Research Achievements |
GPR55 is an orphan G protein-coupled receptor and a putative novel type of cannabinoid receptor. Lysophosphatidylinositol (LPI) is an endogenous ligand for GPR55. It has been reported that GPR55 mRNA expresses in immune system. This study revealed that GPR55 mRNA expression was increased with the progression of maturation of T cells in thymus and was high in T cells in spleen compared to thymus. The level of GPR55 mRNA in B cells derived from bone marrow was higher than those from spleen. The level of GPR55 mRNA changed when the cells were activated. LPI promoted the cell proliferation. It seems that GPR55 and LPI of its endogenous ligand modulate the cell proliferation, cell differentiation and immune response in immune system.
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Free Research Field |
医歯薬学
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