Elucidation of a prostanoid receptor CRTH2-related mechanism in the regulation of higher brain functions

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18874
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pharmacology in pharmacy
• Research Institution: Setsunan University (2016); Osaka University (2015)
• Principal Investigator: Onaka Yusuke 摂南大学, 薬学部, 助教 (90749003)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: PGD2 / 情動機能 / 認知機能 / 炎症 / 統合失調症 / がん

Outline of Final Research Achievements

Prostaglandin D2 receptor, CRTH2, has well studied in the field of peripheral inflammation. Recently, it has revealed that CRTH2 functions in the emotional and cognitive impairments. In this study, it was shown that CRTH2 signaling in the local brain area could regulate the local neural function, and that CRTH2 signaling alternates local neural function related to the cognitive dysfunction, by using pathological animal models. These findings would contribute to understand the detailed role of CRTH2 in emotional and cognitive dysfunctions in pathological states.

Free Research Field

医歯薬学