2017 Fiscal Year Final Research Report
The functional changes of Cav3.2 T-type Ca2+ channel and its regulatory factors in a mouse model for irritable bowel syndrome
Project/Area Number |
15K18882
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pharmacology in pharmacy
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Research Institution | Kindai University |
Principal Investigator |
Tsubota Maho 近畿大学, 薬学部, 講師 (90510123)
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Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | Cav3.2 / 過敏性腸症候群 |
Outline of Final Research Achievements |
This study suggest that functional upreguation of Cav3.2 T-channel has occurred in the mice with butyrate-induced IBS, and thereby direct stimulation of TRPV1, indirect activation via PAR2 stimulation, and TRPA1 stimulation might contribute to colonic hyperalgesia. These findings demonstrate that an important suggestion for elucidating the molecular mechanism of the onset of IBS.
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Free Research Field |
薬理学
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