2017 Fiscal Year Final Research Report
Mechanisms of the immune responses related to adverse reactions of therapeutic mAbs
| Project/Area Number |
15K18884
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pharmacology in pharmacy
|
|---|
| Research Institution | National Institute of Health Sciences |
|---|
Principal Investigator |
TADA Minoru 国立医薬品食品衛生研究所, 生物薬品部, 室長 (50506954)
|
|---|
| Research Collaborator |
AOYAMA Michihiko 国立医薬品食品衛生研究所, 生物薬品部, 研究員
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 抗体医薬品 / Fcγ受容体 |
|---|
| Outline of Final Research Achievements |
The purpose of this study is to analyze immune-related reactions against therapeutic monoclonal antibodies (mAbs) or their variants including impurities, which may induce adverse reactions. We revealed the cytokine- and chemokine-release profiles induced by Fc-engineered mAbs, the recognition of host-cell proteins by pre-existing antibodies in human serum, and the relationship between the characteristic of mAbs aggregates and the activation of Fc gamma receptors.
|
| Free Research Field |
レギュラトリーサイエンス
|
