Quinones-mediated activation of aromatic hydrocarbon receptor through its chemical modification

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18906
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental and hygienic pharmacy
• Research Institution: University of Tsukuba
• Principal Investigator: ABIKO Yumi 筑波大学, 医学医療系, 助教 (80742866)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 親電子物質 / 芳香族炭化水素受容体 / チオール基 / キノン体

Outline of Final Research Achievements

Exposure of cells to electrophilic mono- and bi-cyclic quinones, but not aromatic hydrocarbons (Ahs, parent compounds of electrophiles) and quinones without covalent binding capability, to Hepa1c1c7 cells upregulated CYP1A1 through activation of aromatic hydrocarbon receptor (AhR). These findings suggest that induction of phase-I enzymes regulated by AhR by environmental electrophiles such as mono- and bi-cyclic quinones is a health risk of environmental chemicals exposure.

Free Research Field

環境生物学