Development and assessment for the treatment for oral mucositis caused by chemo- and radiotherapy in cancer patients

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18916
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Teikyo Heisei University (2016-2017); University of Tsukuba (2015)
• Principal Investigator: MOMO Kenji 帝京平成大学, 薬学部, 准教授 (30645552)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口腔粘膜炎 / がん化学療法 / 放射線療法 / インドメタシンスプレー / 院内製剤 / 臨床製剤 / インドメタシン噴霧製剤

Outline of Final Research Achievements

In this study, we clarified a treatment strategy for oral mucositis caused　by　chemo-　and　radio-therapy　in　cancer　patients.　Briefly,　we　used　the　0.25% of indomethacin solution to the mucositis in the oral cavity of 28 cancer patients with oral mucositis. The pain relief was obtained 26 out of 28 (93%) in this study. The absorption of indomethacin after applying indomethacin oral spray in 7 cancer patients was found comparable to the topical indomethacin agents such as patch or lotion. In conclution, we found the indometahcin oral spray was safe and effective in the patients with oral mucositis.

Free Research Field

製剤学