2016 Fiscal Year Final Research Report
Involvement of nutrient composition and intestinal flora on regulation factors of pharmacokinetics
Project/Area Number |
15K18918
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
|
Research Institution | Kanazawa University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
|
Keywords | 薬物動態変動要因 / 栄養環境 / 腸内細菌叢 |
Outline of Final Research Achievements |
Absence of intestinal flora Affect pharmacokinetics of drug, however there was no report whether regulation of intestinal flora by daily life affect drug safe and effective. This study investigated the effects of increment of good bacteria in intestine using the animal model treated dietary fiber and medicine for intestinal disorders. The results showed that water soluble dietary fiber and medicine for intestinal disorders, which increase good bacteria, did not significantly affect pharmacokinetics factors. This study suggested that regulation of intestinal flora in dairy life would not affect pharmacokinetics of drugs.
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Free Research Field |
臨床薬学
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