Development of search method of drug interaction of ARB using medical information database and elucidation of the mechanism

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K18920
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Hori Katsuhito 浜松医科大学, 医学部附属病院, 薬剤師 (20436786)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 薬剤疫学

Outline of Final Research Achievements

In order to examine the utilization method of the medical information database, we examined the method of detecting the interaction, using ARB and immunosuppressant as an example.The ARB average dose in two groups according to the presence or absence of other antihypertensive agents or anti-inflammatory analgesics, but no significant difference was found. Change in blood concentration of the immunosuppressant drug was observed in the patient co-administered with the antibacterial drug that inhibits the metabolic enzyme CYP3A4 of the immunosuppressant drug, no change in the concentration due to the combination was observed.

Free Research Field

臨床薬学

Academic Significance and Societal Importance of the Research Achievements

従来報告されていた医療情報データベースの利活用方法としては副作用の検出が一般的であった。本研究は相互作用を検出する方法を検討したことで、医療情報データベースの新しい利活用方法が提案できると考えられる。