2017 Fiscal Year Final Research Report
Molecular mechanism underling improvement of oxaliplatin-induced neuropathy by duloxetine
Project/Area Number |
15K18922
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | Kyoto University (2016-2017) Kyushu University (2015) |
Principal Investigator |
Kajiwara Moto 京都大学, 医学研究科, 薬剤師(特定) (70645506)
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Research Collaborator |
MASUDA Satohiro 九州大学, 病院薬剤部, 教授・薬剤部長
MATSUBARA Kazuo 京都大学, 医学部附属病院薬剤部, 教授・薬剤部長
NAKAGAWA Shunsaku 京都大学, 医学部附属病院薬剤部, 助教
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | トランスポーター / オキサリプラチン / 末梢神経障害 |
Outline of Final Research Achievements |
HEK293 cells transiently expressing human (h) or rat (r) oraganic cation transporter (OCT) were treated with oxaliplatin (L-OHP) and various concentrations of duloxetine (DLX). Lactate dehydrogenase activity and caspase activity induced by L-OHP was reduced by DLX treatment. Amount of Pt accumulated in cells was also decreased by DLX treatment. Those results suggested that DLX improved L-OHP induced peripheral neuropathy by interfering with L-OHP incorporation in dorsal root ganglion.
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Free Research Field |
トランスポーター
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