2016 Fiscal Year Final Research Report
Significant factors associated with the decrease in CYP3A activity in patients with chronic renal failure
| Project/Area Number |
15K18926
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Oita University |
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Principal Investigator |
Suzuki Yosuke 大分大学, 医学部, 薬物動態解析室主任 (10737191)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | CYP3A / 慢性腎不全 / Phenoconversion / 3-indoxyl sulfate / CYP3A5 |
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| Outline of Final Research Achievements |
The aim of this study was to identify significant factors associated with the decrease in CYP3A activity in patients with chronic renal failure. Compared with before kidney transplantation, plasma 4β-hydroxycholesterol concentrations were significantly elevated on days 90 and 180 after living kidney transplantation. Plasma concentrations of 4β-hydroxycholesterol on days 90 and 180 after kidney transplantation were significantly higher in the presence of the CYP3A5*1 allele than in the absence of the CYP3A5*1 allele. Furthermore, accumulation of indoxyl sulfate was associated with phenoconversion of CYP3A in stable kidney transplant recipients.
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| Free Research Field |
臨床薬理学
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