2016 Fiscal Year Final Research Report
Design and evaluation of folate-modified liposome as a lung-cancer stem cell selective carrier for autophagy inducer or inhibitor drugs
| Project/Area Number |
15K18927
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 肺がん / 経肺投与製剤 / リポソーム / オートファジー |
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| Outline of Final Research Achievements |
In the present study, to make an attempt to confer a lung-cancer stem cell-selectivity to liposome, we newly prepared folate-modified liposome (FA-modified ssLip), and evaluated the potential as its novel lung-cancer stem cell-selectivity carrier for autophagy induced drug or inhibitor drug. Rapamycin loaded FA-modified ssLip showed the potent antitumor activity in KB cells (FR-α (+)) compared to rapamycin alone and unmodified ssLip. Furthermore, FA-modified ssLip improved retention of indo cyanine green in lung after pulmonary administration to rats. In conclusion, the present study demonstrated the potentials of FA-modified ssLip as a novel lung-cancer stem cell-selectivity carrier for autophagy induced drug and inhibitor drug.
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| Free Research Field |
医歯薬学
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