Analyses of endogenous polyunsaturated fatty acid in serum from at-risk mental state subjects

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18936
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Toho University
• Principal Investigator: ONOZATO Mayu 東邦大学, 薬学部, 助教 (50610094)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ARMS / 不飽和脂肪酸 / 血清バイオマーカー / EPA製剤

Outline of Final Research Achievements

Serum concentrations of endogenous compounds, polyunsaturated fatty acid (PUFA) and 3-hydroxybutyric acid (3-HB), between individuals with at-risk mental state (ARMS) and healthy controls were compared. As a result, serum levels of all PUFAs and 3-HB were decreased in accordance with the previous reports in the schizophrenia patients. In addition, we found that serum linoleic acid and oleic acid levels in ARMS were positively correlated with PANSS general psychopathology score.
The commercial EPA ethyl ester was administered orally to male SD rat, and the profiles of PUFA levels in plasma were examined. The concentration of EPA and DHA in plasma significantly increased in the groups that received EPA ethyl ester (100 mg/kg), however, 3-HB levels were not increased.

Free Research Field

分析化学