2017 Fiscal Year Final Research Report
Role of galectin-1 as a target of suppression and prevention for metastasis of renal cell carcinoma
| Project/Area Number |
15K18944
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 臨床薬学 / galectin-1 / 腎臓がん |
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| Outline of Final Research Achievements |
This study was performed to investigate the impact of galectin-1 in metastasis of renal cell carcinoma (RCC). Human RCC-derived ACHN cell line showed a significant increased migration after treatment with galectin-1, which may be mediated by regulation of the cytoskeletal dynamics. Meanwhile, we observed no effect of endogenous galectin-1 on RCC cell lines migration and invasion. This study suggests that galectin-1 can be considered as a target of suppression and prevention for metastasis of RCC.
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| Free Research Field |
臨床薬学
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