Usefulness evaluation of food factors against obesity-related diseases via regulating immune cells functions.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18949
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kyushu University of Health and Welfare
• Principal Investigator: Yoshida Hiroki 九州保健福祉大学, 薬学部, 講師 (90469411)
• Research Collaborator: KUROKAWA Masahiko 九州保健福祉大学, 薬学部, 教授 (80186527) ; WATANABE Wataru 九州保健福祉大学, 薬学部, 教授 (50399218) ; SUGITA Chihiro 九州保健福祉大学, 薬学部, 助教 (70632694)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肥満 / 免疫細胞 / フラボノイド / ナリンゲニン / ヘスペリジン / 食品 / 予防医療 / セルフメディケーション

Outline of Final Research Achievements

We evaluated the preventive and improvement effects of familiar food factors against obesity-related diseases via regulating immune cells functions. Naringenin, a citrus flavonoid, suppressed the infiltration of macrophages, CD8 (+) T cells, B cells and neutrophils into adipose tissue in high-fat diet (HFD)-induced obese mice. Naringenin also suppressed MCP-1, MCP-3 and IL-6 expression in adipose tissue. These molecules are cytokines that influence immune cells functions. In addition, we made clear that hesperidin preparation, another citrus flavonoid, suppressed macrophages infiltration into adipose tissue in HFD-induced obese mice.

Free Research Field

生化学、分子細胞生物学、医療薬科学