2016 Fiscal Year Final Research Report
Mechanism for the maintenance of pseudostratified neuroepithelium
| Project/Area Number |
15K18953
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 神経発生 / 自己組織化 |
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| Outline of Final Research Achievements |
Neuroepithelium is widely observed in developing central nervous systems including cerebral cortex. Neural progenitor cells in neuroepithelium show cell cycle-dependent somatic motion called interkinetic nuclear migration (INM) in apico-basal direction. The purpose of this study is to elucidate how neuroepithelium keep its pseudostratified structure over time in spite of every cell shows INM. We hypothesized stresses in neuroepithelium by in toto time-lapse observation of all nuclei in developing cerebral cortex. Mathematical simulations and in vivo experiments revealed that newborn G1-phase cells in subapical area utilize the restoring force of its surrounding cells for their basal-directed nucleokinesis. These results suggest that the physical properties arised from the neuroepitelial structure assist the displacement of somata/nuclei in subapical area to sustain the pseudostratification.
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| Free Research Field |
発生生物学
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