Analyses of mutual control mechanism between FMR1 and CPEB1.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18958
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Kansai Medical University
• Principal Investigator: OE Souichi 関西医科大学, 医学部, 助教 (70599331)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: FMR1 / CPEB1 / 脆弱X症候群 / 翻訳制御

Outline of Final Research Achievements

The aim of this study is elucidation of the mutual translational control mechanism between FMR1, the causative gene of fragile X syndrome, and CPEB1 which acts as a translational repressor. We showed that CPEB co-localized with Fmr1 mRNA in the rat hippocampal neurons and interacted via CPE in the 3 'UTR. Furthermore, knockdown of CPEB1 increased the expression levels of FMR1 and the mitochondria-related genes.

Free Research Field

神経科学