2016 Fiscal Year Final Research Report
Analysis of ciliary muscle contraction by highly sensitive phos-tag method
| Project/Area Number |
15K18963
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
Takeya Kosuke 旭川医科大学, 医学部, 助教 (20586862)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 毛様体筋 / ミオシン / リン酸化 / カルシウム |
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| Outline of Final Research Achievements |
The ciliary muscle in the eyes controls accommodation for viewing objects with a rapid response and sustained contraction. In general, smooth muscle contraction is regulated by phosphorylation of myosin, a motor protein. When myosin gets phosphorylated, it becomes active and generates contractile force. Interestingly, we found that the phosphorylation level of myosin in ciliary muscle stays high regardless of contractile state, suggesting that an unknown regulator is involved in triggering ciliary muscle contraction. This unknown regulator is activated by increased intracellular calcium, and thus allows quicker response than myosin phosphorylation.
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| Free Research Field |
生理学
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