Searching for the novel signalling molecule in vascular abnormal contraction

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18970
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Yamaguchi University
• Principal Investigator: ZHANG Ying 山口大学, 大学院医学系研究科, 助教 (10711260)
• Research Collaborator: KOBAYASHI Sei 山口大学, 大学院医学系研究科, 教授 ; KISHI Hiroko 山口大学, 大学院医学系研究科, 准教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 血管攣縮 / paxillin / Fyn / Rho-kinase

Outline of Final Research Achievements

Vascular abnormal contraction, known as vasospasm, including cardiovascular and cerebrovascular vasospasm, remains a significant source of morbidity and mortality in sudden death and in patients after subarachnoid hemorrhage. We previously demonstrated that sphingosylphosphorylcholine (SPC) induced this abnormal vascular contraction via a SPC/Fyn/Rho-kinase(ROK) signalling pathway. However, molecular mechanisms between Fyn and ROK remain unclear. In the present study, we identified paxillin as a novel signalling molecule acting downstream of Fyn. Our results indicate that paxillin may be a new therapeutic target for vascular abnormal contraction.

Free Research Field

分子細胞生理学