2017 Fiscal Year Final Research Report
Searching for the novel signalling molecule in vascular abnormal contraction
Project/Area Number |
15K18970
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General physiology
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Research Institution | Yamaguchi University |
Principal Investigator |
ZHANG Ying 山口大学, 大学院医学系研究科, 助教 (10711260)
|
Research Collaborator |
KOBAYASHI Sei 山口大学, 大学院医学系研究科, 教授
KISHI Hiroko 山口大学, 大学院医学系研究科, 准教授
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | 血管攣縮 / paxillin / Fyn / Rho-kinase |
Outline of Final Research Achievements |
Vascular abnormal contraction, known as vasospasm, including cardiovascular and cerebrovascular vasospasm, remains a significant source of morbidity and mortality in sudden death and in patients after subarachnoid hemorrhage. We previously demonstrated that sphingosylphosphorylcholine (SPC) induced this abnormal vascular contraction via a SPC/Fyn/Rho-kinase(ROK) signalling pathway. However, molecular mechanisms between Fyn and ROK remain unclear. In the present study, we identified paxillin as a novel signalling molecule acting downstream of Fyn. Our results indicate that paxillin may be a new therapeutic target for vascular abnormal contraction.
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Free Research Field |
分子細胞生理学
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