Gut Microbiota-Derived Short Chain Fatty Acids Accelerate Food-Induced Circadian Clock Entrainment in Mouse Peripheral Tissue

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18981
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Waseda University
• Principal Investigator: Tahara Yu 早稲田大学, 高等研究所, 助教 (80707399)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 体内時計 / 腸内細菌 / 末梢臓器

Outline of Final Research Achievements

In this study, we demonstrated the effect of microbiota-derived short-chain fatty acid (SCFA) on the circadian clock system in mouse peripheral clocks. Cecal pH was lower and amount of cecal SCFA was higher in the beginning of dark period. Oral injection of SCFA in the daytime caused phase-advance of peripheral clocks. SCFA also caused phase entrainment of cellular clocks in fibroblasts with dose- and time-of-day dependency. In addition, fiber rich diet enhanced food-induced peripheral clock entrainment. Thus, our study revealed first application of chrono-nutrition using microbiota-derived SCFA.

Free Research Field

生物リズム