2017 Fiscal Year Final Research Report
Elucidation of neural mechanism underlying the regulation of feeding rhythm by interaction of the NPY- and histaminergic neurons
| Project/Area Number |
15K18985
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 摂食リズム / 条件給餌 / 摂餌予知 / ニューロペプチドY / Y1受容体 / ヒスタミン神経系 / 弓状核 |
|---|
| Outline of Final Research Achievements |
The aim of this study was to examine an interactive role of neuropeptide Y (NPY) and brain histamine in the regulation of feeding rhythm. When mice were subjected to a scheduled feeding in which food availability is restricted for a few hours in a day, they develop food-anticipatory activity (FAA). Daily rhythm of FAA is controlled independent of light-evoked circadian cycle regulated by a mechanisms involving several clock genes but the mechanism underlying the daily food-anticipation remains elusive. The author demonstrated that mice lacking NPY-receptor (Y-R) manifest markedly reduced FAA. Correspondingly with the reduction of the FAA, activity of the histaminergic neurons in the tuberomammillary nucleus was significantly attenuated. In addition, both anti-histamine and histamine-release blocker reduced FAA. These evidence suggests that the histaminergic neurons were activated through Y-R to elicit FAA.
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| Free Research Field |
神経科学、薬理学
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