2016 Fiscal Year Final Research Report
Mechanism of Axl and Mer dependent efferocytosis of microglia
| Project/Area Number |
15K19009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Yanagihashi Yuichi 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (50611886)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | Axl / Mer / 死細胞貪食 |
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| Outline of Final Research Achievements |
Analysis of Mer defficient mouse revealed that microglia engulfed apoptotic cells through Axl and Mer receptor tyrosine kinase. But, their ability to enhancement efferocytosis and requirement of their ligand - Protein S and Gas6 were not quantitatively determined. In this study, microglial efferocytosis was characterized by quantitative analysis of the ability to enhancement of efferocytosis and comparison between microglia and various macrophages.
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| Free Research Field |
細胞生物学
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