2016 Fiscal Year Final Research Report
The functional analysis of cancer development and progression
| Project/Area Number |
15K19017
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
|
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| Research Institution | Nihon University |
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Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | がんゲノム / 転写因子 |
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| Outline of Final Research Achievements |
Since the HNF4A knockout mouse exhibits tumor development in the liver, it has been suggested that HNF4A loss-of-function mutations triggerliver cancer development and its progression. However, comprehensive functional analysis for the mutations in human liver cancer have not been performed. This study allows us to investigate for the first time the importance of HNF4 mutations in liver cancer.Our study has revealed that HNF4 mutations would casue crucial mutations by loss or reduce of the function of HNF4A.
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| Free Research Field |
分子生物学
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