Identification of novel molecules that improve the transplantation efficiency of muscle stem cells based on their intracellular metabolic state

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19018
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: Ito Naoki 東京大学, 医科学研究所, 特別研究員(PD) (50746534)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 骨格筋 / 幹細胞 / 筋衛星細胞 / 細胞移植治療

Outline of Final Research Achievements

Transplantation of muscle stem cell is one of the promising therapy for several muscle diseases, including Duchenne muscular dystrophy. Satellite cells are the tissue-specific stem cells in skeletal muscle that provide an important cell source for transplantation therapy. However, because satellite cells are composed of functionally heterogeneous population, only a small proportion of satellite cells are engraftable in transplanted muscle, which limit the potential of cell transplantation therapy. We developed the novel technology to separate functionally heterogenous populations based on their intracellular metabolic state. In this study, we aim to identify novel molecules that improve the transplantation efficiency of satellite cells based on the molecular background of more undifferentiated stem cells. Our study will contribute to the development of new approach for cell transplantation therapy.

Free Research Field

骨格筋