The role of ST2, a receptor for cytokine IL-33, in the pathogenesis of cancer/autoimmune disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19031
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Tokyo University of Science
• Principal Investigator: KAMACHI Fumitaka 東京理科大学, 理工学部応用生物科学科, 助教 (00747800)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ST2

Outline of Final Research Achievements

The pathogenesis of multiple sclerosis, an autoimmune disease affecting the brain and spinal cord, remains poorly understood. Although obesity is known to be a risk factor for several types of cancer including hepatocellular carcinoma, the exact mechanisms have remained largely unclear. In this study, we tried to investigate whether ST2, a receptor for cytokine interleukin-33, could be a therapeutic target for multiple sclerosis and obesity-associated hepatocellular carcinoma. We found that the inhibition of ST2 signaling attenuated the symptoms of multiple sclerosis model mice and the development of obesity-associated hepatocellular carcinoma in mice.

Free Research Field

免疫学