2017 Fiscal Year Final Research Report
The role of ST2, a receptor for cytokine IL-33, in the pathogenesis of cancer/autoimmune disease
Project/Area Number |
15K19031
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pathological medical chemistry
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Research Institution | Tokyo University of Science |
Principal Investigator |
KAMACHI Fumitaka 東京理科大学, 理工学部応用生物科学科, 助教 (00747800)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | ST2 |
Outline of Final Research Achievements |
The pathogenesis of multiple sclerosis, an autoimmune disease affecting the brain and spinal cord, remains poorly understood. Although obesity is known to be a risk factor for several types of cancer including hepatocellular carcinoma, the exact mechanisms have remained largely unclear. In this study, we tried to investigate whether ST2, a receptor for cytokine interleukin-33, could be a therapeutic target for multiple sclerosis and obesity-associated hepatocellular carcinoma. We found that the inhibition of ST2 signaling attenuated the symptoms of multiple sclerosis model mice and the development of obesity-associated hepatocellular carcinoma in mice.
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Free Research Field |
免疫学
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