Epigenetic regulation of inflammatory genes associated with the rupture of intracranial aneurysms

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19043
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human genetics
• Research Institution: National Institute of Genetics
• Principal Investigator: Nakaoka Hirofumi 国立遺伝学研究所, 総合遺伝研究系, 助教 (70611193)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 脳動脈瘤 / くも膜下出血 / マクロファージ / 炎症反応 / エピジェネティクス

Outline of Final Research Achievements

In our previous study, we demonstrated that macrophage-mediated inflammation is a key biological pathway for the rupture of intracranial aneurysms. We focused on the inflammatory transcription factors associated with the rupture of intracranial aneurysms. We explored the expression profiles of genes with binding motifs of these transcription factors, and constructed a hierarchical transcriptional regulatory networks associated with the rupture of intracranial aneurysms. We performed epigenetic analysis of these genes.

Free Research Field

統計遺伝学