Comprehensive lipid analysis in malignant lymphoma tissue

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19048
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: YAMAMOTO Kohei 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (50451927)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 悪性リンパ腫 / ホジキンリンパ腫 / 脂質 / Lipidomics

Outline of Final Research Achievements

Comprehensive lipid analysis in Hodgkin-Reed Sternberg(HRS) cells was performed using imaging mass spectrometry. A total of seven m/z had significant differences between HRS cell and surrounding reactive lymphocytes. Among them, m/z 885.5 was decreased in HRS cells, whereas other m/z group were relatively increased. MS/MS analysis revealed that all the m/z were phosphatidyl inositol (PI). In detail, m/z885.5 was mature type of PI(18:0/20:4), on the other hand, other m/zs were de novo PI(e.g. PI(18:0/18:1), PI(18:0/18:2)).

Free Research Field

血液病理学