The role of tumor-infiltrating macrophages in the chemoresistance of esophageal squamous cell carcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19058
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Keio University
• Principal Investigator: Ohara Kentaro 慶應義塾大学, 医学部(信濃町), 助教 (40571724)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 食道がん / 抗癌剤耐性 / マクロファージ

Outline of Final Research Achievements

To elucidate the role of tumor-infiltrating macrophages in the chemoresistance of esophageal squamous cell carcinoma (ESCC), we performed immunohistochemical analysis of CD68 and CD204 in ESCC. Infiltration of CD204-positive cells was significantly associated with several agressive pathological factors, including poor chemotherapeutic response. Patients with high infiltration of CD204-positive cells presented a worse prognosis than low infiltration of CD204-positive cells, but this difference did not reach statistical significance. Subsequently, we examined the ADAM10 protein expression by immunohistochemical staining, and found that ADAM10 overexpression was significantly correlated with high infiltration of CD204-positive cells. It is suggested that CD204-positive macrophages may play an important role in the chemoresistance of ESCC through overexpression of ADAM10 protein.

Free Research Field

人体病理学