2017 Fiscal Year Final Research Report
Carcinogenesis mechanism of gastric adenocarcinoma of fundic gland type
Project/Area Number |
15K19060
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | Juntendo University |
Principal Investigator |
UEYAMA Hiroya 順天堂大学, 医学部, 准教授 (60621935)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 胃癌 / 胃底腺型胃癌 / 次世代シークエンス / GNAS mutation |
Outline of Final Research Achievements |
Gastric adenocarcinoma of fundic gland type (GAFG) is classified into pure GAFG and gastric adenocarcinoma of fundic gland mucosal type (GAFGM) which exhibited differentiation toward gastric foveolar epithelium in addition to fundic gland differentiation, histopathologically. This histopathological classification of GAFG is useful to estimate its malignant potential. The comprehensive genetic analysis using next generation sequencing of GAFG identified that GAFG is a neoplasm with low-grade malignancy, and the frequent presence of GNAS mutation is a characteristic genetic feature of GAFG, both pure GAFG and GAFGM (GAFG: 21.4%, pure GAFG: 19.0%, GAFGM: 28.6%). We will verify the specificity of obtained oncogenic driver mutations and speculate the signaling pathway of carcinogenesis of GAFG.
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Free Research Field |
消化器癌の発癌
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